ARIXTRA PRESCRIBING INFORMATION PDF

GSK has halted all shipments of ARIXTRA Starter Kits containing the Triad For important product information, log onto Arixtra mg/ ml solution for injection, pre-filled syringe. 2. .. Detailed information on this medicinal product is available on the website of the European . Arixtra is a medicine that helps prevent blood clots from forming in the blood This medicinal product contains less than 23 mg of sodium in each dose and.

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A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Platelet function or global clotting function tests e.

Epidural or ariztra hematoma reported with concurrent use of anticoagulants e. Usual duration of therapy is 5—9 days, 1 3 4 5 6 although up to 11 days has been studied in clinical trials of orthopedic surgery.

Initiate concurrent warfarin as soon as possible, 1 usually within 72 hours of fondaparinux injection; 1 20 ACCP recommends initiating warfarin simultaneously arixhra the first day of fondaparinux treatment.

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In healthy adults, distributes mainly in infprmation and only to a minor extent in extravascular fluid. Research Triangle Park, NC: Evaluate the possibility of an underlying bleeding disorder before initiation of treatment. Optimal timing between administration of fondaparinux and neuraxial procedures not known. No specific dosage recommendations; however, careful attention to dosage directions recommended.

Randomized informqtion trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip- fracture surgery. Arixtrq general, pharmacologic thromboprophylaxis is recommended only in such patients considered to be at high risk of venous thromboembolism.

The pharmacokinetics of fondaparinux sodium in healthy volunteers. Eliminated unchanged in urine in individuals with normal renal function. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. Anticoagulant effects may persist for 2—4 days following discontinuance of therapy in patients with normal renal function i. Synthetic pentasaccharides do not cause platelet activation by antiheparin-platelet factor 4 antibodies.

A synthetic pentasaccharide for the jnformation of deep- vein thrombosis.

Arixtra Monograph for Professionals –

Bounameaux, H, Perneger T. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Hull R, Pineo G.

Prevention of VTE in nonorthopedic surgical patients: Prevention of postoperative DVT and PE in patients undergoing hip-fracture, hip-replacement, or knee-replacement surgery. Importance of informing patients that concomitant use of aspirin or other NSAIAs can increase risk of bleeding, and to discontinue use of these drugs whenever possible.

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Distributed into milk in rats; not known whether distributed invormation human milk. Extended thromboprophylaxis for up to 35 days is recommended in patients undergoing hip arixxtra surgery, 40 and suggested for patients undergoing other major orthopedic procedures.

Periodic routine blood counts, including platelet counts, and tests for occult blood in stool recommended. ACCP recommends fondaparinux as an option for thromboprophylaxis in acutely ill, hospitalized medical patients at increased risk of thrombosis. Used in conjunction with warfarin for treatment of DVT and acute PE when initial therapy is administered in the hospital.

When selecting an appropriate thromboprophylaxis regimen, consider factors such as relative efficacy, bleeding risk, logistics, and compliance issues. Arixtra fondaparinux sodium injection prescribing information. Discontinue NSAIAs prior to initiation of fondaparinux 1 40 If coadministration is essential, arixtda patients closely Antithrombotic therapy for VTE disease: Usual duration of therapy is 5—9 days, although up to 26 days of treatment has been prescribin. If coadministration is essential, monitor patients closely 1 Some packaging components e.