ELIGARD PACKAGE INSERT PDF

ELIGARD (leuprolide acetate) is indicated for the palliative due to incorrect reconstitution or administration of the product (see Monitoring and Laboratory .. Gently insert the long, white replacement plunger rod into the gray. PACKAGE LEAFLET: INFORMATION FOR THE USER. ELIGARD 45 mg powder and solvent for solution for injection. Leuprorelin acetate. Read all of this leaflet. Eligard® is a sterile polymeric matrix formulation of leuprorelin acetate for subcutaneous package insert for constitution and administration procedures.

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GnRH analog therapy increases the risk of reduced bone mineral density in men as well as women, and may have particular relevance for the geriatric population. Dysfunctional uterine bleeding, menstruation, vaginal bleeding. Initially, there is a surge of FSH and LH, which can cause a flare reaction in prostate or breast carcinoma. Major Clarithromycin is associated with an established risk for QT prolongation and torsades de pointes TdP.

Withhold HCG administration in cases where the ovaries are abnormally enlarged to reduce the chance of inducing ovarian hyperstimulation syndrome OHSS. Patients with urinary tract obstruction or metastatic vertebral lesions should be monitored carefully for signs of renal impairment or spinal cord compression, respectively, during initial leuprolide treatment. Allow the product to reach room temperature before mixing. The recommended dose is 15 mg IM as a single dose repeated every 4 weeks.

Case reports suggest standard monthly injections of 1. Mix the product by pushing the contents of both syringes back and forth between the syringes approximately 45 seconds to obtain a uniform suspension.

The QT prolongation appeared less with alfuzosin 10 mg than with 40 mg. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include dolasetron.

Such therapy does not compromise the efficacy of leuprolide in relieving endometriosis symptoms and may also reduce vasomotor symptoms and vaginal dryness associated with hypoestrogenism. Severe Thioridazine carries a known risk for QT prolongation ppackage torsade de pointes TdPand is contraindicated for use with other medications that may prolong the QT interval. Major Halogenated anesthetics are associated with a risk for QT prolongation and potential cardiac arrhythmias.

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Eligard (leuprolide acetate) dose, indications, adverse effects, interactions from

In the female, it stops estrogen production in the ovaries. Lofexidine prolongs the QT interval. The use of GnRH analogs in men has been reported in association with an increased risk of myocardial infarction, sudden cardiac death, and stroke. If present, blood can be seen through the transparent LuproLoc safety device and would be visible just below the luer lock connection. Drugs with a possible risk for QT prolongation and Isnert that should be used cautiously with leuprolide include panobinostat.

Therefore, contraception requirements such as non-hormonal methods are required. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with chloroquine include leuprolide.

Although there are no studies examining the effects of artemether in isert receiving other QT prolonging drugs, coadministration of such inserg may result in additive QT prolongation and should be avoided.

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Leuprolide should only be used by a qualified infertility specialist. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include ketoconazole.

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include mefloquine. Severe Pimozide carries a known risk for QT prolongation and torsade de pointes TdPand is contraindicated for use with other medications that may prolong the QT interval. Major Monitor patients for QT prolongation if coadministration of leuprolide with sunitinib is necessary.

Major Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produce an increase in QTc interval e. Children 1 to 12 years. Major Androgen deprivation therapy e. When vardenafil 10 mg was paclage with another drug that is known to cause QT prolongation, an additive effect on the QT interval was observed. Elibard is also considered a drug with a possible risk of TdP.

While the Lupron Depot-Ped product is indicated for use in children, the Viadur implant and Eligard brands of leuprolide are contraindicated in children and adolescents due to limited experience. Because of the potential for TdP, use of bepridil with leuprolide is contraindicated. Like the naturally occurring hormone, leuprolide can be metabolized in the anterior pituitary and hypothalamus.

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Elgiard of the potential for QT prolongation and torsade unsert pointes TdPuse of these drugs together should be avoided. Major Avoid coadministration of inotuzumab ozogamicin with leuprolide due to the potential for additive QT prolongation and risk of torsade de pointes TdP.

The risk of myocardial infarction, sudden cardiac death, and stroke appears low but needs to be evaluated carefully along with cardiovascular risk factors like cardiac disease, tobacco smoking, hypertension, hypercholesterolemia, and obesity. Drugs with a eligarv risk for QT prolongation and TdP that should be used cautiously with leuprolide include beta-agonists. Since leuprolide suppresses the pituitary-gonadal axis, diagnostic tests for pituitary insufficiency or other pituitary-gonadal function conducted during treatment and after cessation of therapy may be misleading.

Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such insegt leuprolide. Major Although data are limited, coadministration of efavirenz and leuprolide may increase the risk for QT prolongation and torsade de pointes TdP.

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While no drug interactions have been reported with leuprolide, therapy with androgens would be relatively contraindicated and would counteract the therapeutic effect of leuprolide. Major Avoid coadministration of leuprolide with osimertinib if possible due e,igard the risk of QT prolongation and torsade de pointes TdP.

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with elugard include ibutilide. Screw the white plunger into the end stopper until the stopper begins to turn. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with hydroxyzine include leuprolide.

Leuprolide subcutaneous injections should epigard used with caution in patients with known benzyl alcohol hypersensitivity. Prepare the 2 syringes for mixing per manufacturer’s instructions.

According to inserh manufacturer, bepridil is contraindicated for use with drugs that prolong the QT interval due to the risk of TdP.

Do not use partial syringes or a combination of syringes to achieve a particular dose or to titrate dosages.