PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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It belongs to the family Rutaceae [ 2 ]. A herbarium specimen of this plant has been deposited at Principal K.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

Shri Satguru Publication 3: Guidelines Upcoming Special Issues. RESULTS In carrageenin induced hind paw edema method, the oral administration of VN in graded dosesand mg kg -1 produced significant reduction in paw volume in dose dependent manner in comparison to control. The present study indicated VN to possess significant anti-inflammatory activity in dose dependent manner against acute as well as sub-acute inflammatory experimental models.

We also extend our sincere thanks to Dr. Fundamental of Experimental Pharmacology. The inflajmatory in wet and dry weights of granuloma from control group to that of treated group indicates the anti-inflammatory activity.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

Please review our privacy policy. Support Center Support Center. The effects were compared with phenylbutazone mg kg -1 orally in carrageenin induced hind paw edema method and ibuprofen mg kg Crushed leaves are applied externally cures skin eruption and to relieves burn. The tubes were then centrifuged at rpm for 10 min nebundo cooled.

The anti-inflammatory activity was studied by using carrageenan induced paw edema in rats. Effect of Vitex negundo extract on oxidative stress by plasma estimation of malondialdehyde MDA.


Kundnani College of Pharmacy.

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Volume of the injected paw was measured plethysmographically immediately after the injection and then again at hourly intervals up to 4h. Albino rates of either sex weighing gm were procured from Animal House of Kota College of Pharmacy, Kota, Rajasthan, and were selected in the study. In this study, VN extract showed inhibiting effect on oxytocin induced rat uterus contractions in a dose dependent manner.

Can’t read the image? Moreover, leaves of VN are known to possess various anti-oxidant chemical constituents like flavonoids Banerji et al. Please leave a message, we will get back you shortly. Gum acacia, phosphoric acid, potassium ferricyanide, ferric chloride were of LR grade and obtained from local suppliers.

The anti-inflammatory effect persisted for varied time as 3, 5 and 6 h in different dosesand mg kg -1respectively Table 1. It was identified and authenticated by an expert botanist from J.

The total methanol extract of the plant was standardized in terms of total polyphenols. Although, leaves of VN have been investigated for its anti-inflammatory activity in past Telang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pharmacological Experiment on Isolated Preparations.

Patel Road, Bilimora, D: The action started at half an hour except with mg kg -1 dose of the test drug, where it was delayed to 1 h. Two methods were employed to evaluate the anti-inflammatory activity as well as potentiation effect of phenylbutazone and Ibuprofen anti-inflammatory action by VN.

The oxidative stress is the condition where Reactive Oxygen Species ROS generation exceeds endogenous anti-oxidant defense Sen, and it is well known that in chronic and sub-acute inflammation reactive oxygen species play an important role in modulating the extent of inflammatory response and consequent tissue and cell injury Robbin et al. The basic literature survey exposed that Vitex negundo hasantioxidant, antiulcer and anti-nociceptive activity and Murraya koenigii possessing anthelmintic, analgesic, cooling activity, but not many scientific studies have been carried out to reveal and collaborate the anti-inflammatory activity of Vitex negundo and Murraya koenigii leaves.


Effect of Vitex negundo extract on oxytocin induced contractions in rat uterus. Oxygen toxicity and antioxidants: Total yield of extract was Screening of anti-inflammatory activity of certain indigenous drugs on carrageenin induced hind paw oedema in rats. The activity was evaluated by using carrageenan induced paw edema in rats.

Robbins, Pathologic Basis of Disease. The antiinflammatory activity was carried out on Wistar rats using the carrageenan-induced rat paw method 11 J Lab Clin Med. The paw volume was measured first at half an hour and then at 1, 3, 5 and 6 h after administration of drugs. Used by Meir et al. D I Toxicant control Carrageenan 0.

Similarly, fresh leaves of VN have been suggested to possess anti-inflammatory and pain suppressing activities possibly mediated via PG synthesis inhibition, antihistamine, membrane stabilising and antioxidant activities Dharmasiri et al.

How to cite this article: More over anti-ulcer activity of VN reported by Sahni et al.

The reaction mixture contained 0. Vitex negundo and Murraya koenigii are popular Indian herbs which are used for various clinical disorders.