Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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This can be due to the fact that an increase in polymer concentration led to an enhancement of the concentration gradient between emulsion droplets and the continuous euvragit, as a result increasing the amount of drug partitioning into the continuous phase [ 38 ]. Many researchers investigated various natural, semi-synthetic and synthetic polymeric materials.
Figure 2 provides the 3D response surface plots showing the change of particles size corresponding to the change of independent variables.
View at Google Scholar A. The objective of present study was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir. The ingredients were passed through a mesh sieve. The contents, results, and technical data from this site may not be reproduced either electronically, photographically or substantively without permission from MatWeb, LLC. Subscribe to Premium Services Searches: The reduced mathematical models for mean particle size, Ejdragit, average zeta potential, and PDI euddragit presented by 4 to 7respectively.
Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to favor less penetration of the dissolution medium in the tablets. The 3D surface plots illustrating the effects of independent variables on mean particle size, EE, average zeta potential, and PDI are shown in Figures 2 — 5respectively. There is minimal drug loss during transit through the gastrointestinal tract while the particles evade degradation in the acidic environment of the stomach.
Factors with values that are less than 0. Tenofovir was encapsulated in Eudragit RS PO in this study intended for oral administration since most studies are based on the prevention of HIV transmission [ euxragit ].
The results are expressed as mean standard deviation SD. Although Eudragit RSPO eudratit been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been evaluated.
The influence of the repo concentration in the tablets was also investigated. Figure 6 in vitro cumulative release of metformin. However, the release of a drug in acidic media pH 1.
The equation explaining the effect of independent factors on PDI is shown in 7 below. The same profile was observed in Figure 3 b.
All other chemicals used were of analytical grade and purchased from Sigma-Aldrich South Africa. In each formulation, the amount of the active ingredient is mg and the total weight of a tablet is mg. In order to compare the release profile of different formulas with possible difference in release mechanisms n valuesa mean dissolution time MDT [ 14 ] was calculated using Eq.
Figure 3 in vitro cumulative release of metformin. We advise that you only use the original value or one of its raw conversions in your calculations to minimize rounding error. Concentration of drug released was determined using UV spectrophotometer.
The samples were prepared using a double adhesive tape stuck to an aluminium stub. However, the use of hydrophilic matrix alone for extending drug release for highly water soluble drugs is restricted due to rapid diffusion of the dissolved drug through the hydrophilic gel network.
The coefficient of determination of the model for mean particle size was 0. It is a solid substance in form of white powder with a faint amine-like odour. Tenofovir nanoparticles were prepared using modified nanoprecipitation method [ 24 ] in accordance with BBD Table 2.
Time-controlled Drug release
Sink condition was maintained for the whole experiment. The direction of the magnitude of significance as shown in 5 was negative for ratio of a polymer to eudrgait drug eudgagit an inverse relationship between ratio of a polymer to a drug and EE. The tablets were prepared by wet granulation method. An identical release profiles were observed in both dissolution media, which is due to the fact that Eudragit RS PO eudgagit pH independent; the release of drug is dependent on the diffusion of the drug from the matrix of the polymer.
Side effects, short half lives, low bioavailability and the need for the administration two to three times a day when larger doses are required can decrease patient compliance. To receive news and publication updates for Journal of Nanomaterials, enter your email address in the box below. While in the systemic circulation the nanoparticles extend the half-life of the drug and release it in a sustained manner.