Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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Prevention It is recommended that women be treated with a single anticonvulsant prior to conception and throughout pregnancy, since it appears that children exposed to multiple anticonvulsants may be at a greater risk for significant birth defects.

Manifestations include dysmorphic craniofacial features, hypoplastic distal phalanges and nails, growth delay and delayed psychomotor development. Radiograph of 85 Click here to view. Summary fetla related texts. There is no diagnostic testing that can identify fetal hydantoin syndrome.

Various methods of rehabilitative and behavioral therapy stndrome be beneficial. The range and severity of associated abnormalities may vary greatly from one infant to another.

Front profi le Click here to view. The neurological effects of phenytoin exposure in utero have not been clearly established by studies, which have demonstrated conflicting results. Studies have indicated that fetal valproate syndrome is associated with greater risk of neurological and cognitive abnormalities than other anti-seizure medications.


Fetal hydantoin syndrome – Wikipedia

High arch palate Click here to view. Prenatal prediction of risk of the fetal hydantoin syndrome.

Inguinal hernia is when a portion of the intestines pushes through syndromme muscular layers of the abdominal wall. Seizure Disorders in Pregnancy. Search other sites for ‘Fetal Hydantoin Syndrome’. Elsevier Saunders, Philadelphia, PA; You can help by adding to it.

Fetal Hydantoin Syndrome

Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome. Some current clinical trials also are posted on the following page on the NORD website: Search Bing for all related images. Signs Microcephaly Growth delay Mental Retardation and Developmental Delay Craniofacial dysmorphic features Flat nasal bridge Epicanthic folds Prominent upper lip over wide mouth Distinguishing characteristics Nail and distal phalanx hypoplasia Hypertelorism.

Back Syndroke pages that link to this page. The range and severity of associated abnormalities will vary greatly from one infant to another. Genetic differences in formation of these free radicals, drug clearance, and repair mechanisms may explain different susceptibility across individuals.

Fetal hydantoin syndrome

Heart defects and cleft lip [3] may also be featured. Buehler BA, Finnell R.


Generally surgeons repair the lip when the child is still an infant. Researchers believe that the protein product of this gene plays a role in the proper breakdown metabolism of phenytoin or one of its metabolites. Methemoglobinemia is a rarely seen side effect. Additional information Further information on this disease Classification s 6 Gene s 0 Clinical signs and symptoms Publications in PubMed Other website s 3.

NORD has a separate report on fetal valproate syndrome.

NeonatalAntenatal ICD Orphanet Encyclopedia, February Differential Diagnosis Fetal Alcohol Syndrome. Counseling is recommended for women to discuss the risks that seizures prevent for both the developing fetus and the expectant mother as well as the risks to the developing fetus involved fetzl taking anti-seizure medications during pregnancy.

Churchill Livingston Elsevier; D ICD – Years Published, NORD has a separate report called fetal valproate syndrome that discusses infants whose mothers took valproate during pregnancy. This section is empty. Some infants and children may experience delays in uydantoin developmental milestones such as learning to sit up or crawl developmental delays.