Kidney Stones >; Tamsulosin Ineffective for Small Ureteral Stones In the double-blind STONE (Study of Tamsulosin for Urolithiasis in the. Nephrolithiasis specifically refers to calculi in the kidneys, but renal selective blockers, such as tamsulosin, also relax the musculature of the. Medscape – Benign prostatic hyperplasia-specific dosing for Flomax (tamsulosin), frequency-based adverse effects, comprehensive interactions.

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This was a randomized, open-label trial similar to the Lee article. Medical expulsive therapy for ureteral stones—Stone Age medicine.

The Use of Alpha-Blockers for the Treatment of Nephrolithiasis

Alphaadrenergic receptor antagonists have some degree of selectivity for the detrusor and the distal ureter neephrolithiasis have therefore been the next agents investigated for their potential to promote stone expulsion and decrease pain. Cervenakov I et al Now, though, we have better evidence to guide our decisions. Patients discharged on parenteral diclofenac not standard care for us This is the only randomized trial to show a benefit to tamsulosin but there are some major issues.

Similar results were seen when the entire length of the ureter was exposed to adrenaline and noradrenaline.

Tamsulosin (Flomax) – Side Effects, Dosage, Interactions – Drugs

Only 1 patient receiving tamsulosin experienced slight dizziness. Once we make a diagnosis, our primary goal in the ED is pain relief.


Non-blinding design would favor drug but no benefit anyway. Sustained contraction of smooth muscle in the ureter as a kidney stone passes the length of the ureter leads to pain.

Steinstrasse is an accumulation of stone fragments in the ureter typically after SWL, which can lead to obstruction. Multicenter, randomized, double-blind, placebo-controlled study.

Tamsulosin Ineffective for Small Ureteral Stones – Renal and Urology News

The following two tabs change content below. The role of adrenergic blockade in the treatment of ureteral colic. Clearly, there is disagreement in the literature.

The systematic review data from the Lancet and Ann of EM in are minimally, if at all, useful. Blood Transfusions, Lidocaine for August 17, at 5: Stone passage as reported by patient Primary Outcome Tamsulosin Tamsulosin should not routinely be prescribed to patients with ureteral colic and, at this point, it is unclear if there is any subgroup that nephrollthiasis benefit.

Tamsulosin Ineffective for Small Ureteral Stones

They compared 2 groups of 30 patients each: The 86 patients were broken down into 3 groups: All patients received an oral steroid deflazacort for 10 days, clotrimoxazole for 8 days, and diclofenac as needed. NSAIDs also have the potential to decrease inflammation and mucosal edema and are useful for analgesia during stone passage, but have not been proven to be successful in stone passage when used alone.


The passage rate for ureteral stones less than 9 mm in diameter did not differ significantly between tamsulosin and placebo recipients, study finds. Read Next Tamsulosin Reviews.

Both tamsulosin and nifedipine significantly reduced the need for diclofenac when compared with the control group. Distal ureteric stones and tamsulosin: Medical-expulsive therapy for distal ureterolithiasis: Effect of tamsulosin on passage of symptomatic ureteral stones.

Abstract Medical expulsion therapy has been shown to be a useful adjunct to observation in the management of ureteral stones.

Because ureteral edema and ureteral spasm have been postulated to affect stone passage, these effects have been targeted for pharmacologic intervention. In a more nephroltihiasis prospective study, De Sio and associates 20 showed similar results.

Although these approaches are less invasive than traditional open surgical approaches, they are expensive and have inherent risks. Patients were evaluated 15 days after receiving SWL with abdominal radiography to evaluate for residual stone burden. Alpha Blockers in Renal Colic: I always use the haircut analogy.

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