Heterociklična jedinjenja su ciklična jedinjenja koja pored ugljenika sadrže u strukturi prstena jedan ili više atoma nekih drugih elemenata-. Start studying Heterociklična jedinjenja (Petočlana). Learn vocabulary, terms, and more with flashcards, games, and other study tools. izvor: Wikipedia. Stranice: Poglavlja: Heterociklična Jedinjenja (2 prstena), Heterociklična Jedinjenja (3 prstena), Heterociklična Jedinjenja (4 ili više.

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Misic-Vukovic, Synthesis of substituted 3-cyanopyridones: Shi, New potential calcium channel modulators: Shen, The 2-pyridone antibacterial agents: Winscom, Photographic elements containing a de-aggregating compound and dyeforming coupler, Eastman Kodak Co. In the beginning, the synthesis was performed using conventional microwave ovens. Oertel, Safety and efficacy of perampanel in advanced Parkinson’s disease: Konvencionalni nacin izvodenja organskih sinteza podrazumeva zagrevanje spoljasnjim izvorima toplote pri cemu se toplota prenosi kondukcijom, sto predstavlja spor i neefikasan metod prenosa energije, jer zavisi od toplotne provodljivosti materijala, pa je temperatura reaktora veca od temperature reakcione smese.

BoxBelgrade, Serbia. Because of the various applications of compounds that contain 2-pyridone structure a number of procedures for their synthesis was developed.

Zbog siroke primene jedinjenja koja u sebi sadrze piridonsku strukturu razvijen je veliki broj postupaka za njihovu sintezu. In addition to these products a derivative of 2-hydroxyphenylcyanopyridones was also obtained Table 1, entry Visser, Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones heterocik,icna solvent-free conditions, Tetrahedron Lett.

Heterociklično jedinjenje

Almqvist, Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones, Top. Most of these compounds possess antibacterial [2,3], antifungal [4], anti-inflammatory [5], antiviral [6,7], antitumor [8] and antiplatelet [9,10] properties.

Also, the microwave technique is used heterpciklicna the food industry as well as in the pyrolysis of waste materials [46], the preparation of samples for analysis [47], extraction of natural products [48] and hydrolysis of proteins and peptides [49].

Brkovic and Aleksandar D. Microwave synthesis is among methods that respect the principles of the so-called “green chemistry” which is one more reason for performing this type of synthesis [50].


Instead of p-toluenesulfonic acid, silica gel or aluminum oxide can be used, but yields were lower with longer reaction times. First, we will discuss the microwave synthesis of 2-pyridones.

Heterociklično jedinjenje — Википедија, слободна енциклопедија

The product, of high purity, can be obtained from the reaction mixture by simple filtration. The nucleophilicity of the nitrogen is increased and therefore both reactions, the condensation with the malonic ester and the ring closing acylation proceed faster Figure 5. This type of synthesis involves the reaction of phenylazo carbonyl compounds and cyanoacetamide using KOH as base and ethanol as solvent in a dedicated microwave reactor.

The advantage of this synthesis is short reaction time, efficiency and use of water instead of organic solvents which have a favorable impact on the environment. The Bookmark will be sent with the above message.

On the other hand, microwave irradiation is an efficient way of heating where energy is transmitted directly through interaction with polar molecules present in the reaction mixture [40,41]. Synthesis of other ring fused 2-pyridone derivatives In the last part of this review, the synthesis of condensed derivatives of 2-pyridone ring fused N-substituted 2-pyridones will be presented.

A good example of such a combination is given in a paper by Gorobets et al. Pregled obuhvata sinteze koje su izvrsene kako u savremenim laboratorijskim mikrotalasnim reaktorima tako i one koje su izvrsene u komercijalnim mikrotalasnim pecnicama za domacinstvo. At the end of the review several examples of microwave synthesis of other 2-pyridone based compounds ring fused W-substituted 2-pyridones are given.

Mohan, Bismuth Compounds in Organic Synthesis.


Health, A 46 Kappe, Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries, Tetrahedron 60 This synthesis is given in Figure 2. In this manner, carbostyril analogues can be synthesized Figure It should be pointed out that a significant number of papers on the reactions of functionalization of 2-pyridone ring exist.


The products were obtained in high yields and in a short reaction time up to 7 minwhile the conventional method of synthesis required up to 4 h with lower yields Figure 4. Loupy, Solvent-free synthesis of 4-aryl substituted 5-alkoxycarbonylmethyl-3,4-dihydropyridones under microwave irradiation, Tetrahedron Lett. N-substituted 4,6-dimethylcyanopyridones were obtained from acetylacetone and the corresponding W-substituted cyanoacetamide using conventional and microwave synthesis in the presence of piperidine as a catalyst.

Cyclization of cyanoacetamide with 1. Petrovic, Milrinon-svojstva i sinteza, Hem. Farah, The search for a digitalis substitute II milrinone Win its action on the heart-lung preparation of the dog, Life Sci.

However, the use of microwave irradiation has a number of advantages over both conventional methods: It was demonstrated that the sulfur in the pilicide scaffold could be exchanged for oxygen with an almost retained pilicide activity.

Microwave technology is used in both synthetic steps. The mechanism of the reaction is complex and involves Knoevenagel reaction, addition of Michael or Perkin reaction, whereby the degree of enolyzation of dioxo compounds determines the participation of Michael addition [30,31]. For example, the modern pharmaceutical industry requires the creation of a growing number of new molecules, forcing chemists to conduct a number of experiments in a short period of time [45]. This method cannot be applied in cases where an electron-acceptor group e.

Different combinations of fragments were used: Microwaves have a frequency between 0.

Derivati 2-piridona su posebno interesantni jer je 2-piridonska struktura prisutna u mnogim jedinjenjima prirodnog porekla od kojih mnoga poseduju biolosku aktivnost. Shi, An efficient and greener approach to the synthesis of 3,5-dicyanopyridin-2 1H -one derivatives in aqueous media under microwave irradiation conditions, J.