Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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Except for a longer sleep time, IN DEX was not associated with a higher incidence of adverse events when compared to a cohort that did not receive DEX sedation. No significant change was observed in SpO 2 between the groups until the end of 30 min.

Since this drug has a neutral pH it is virtually painless when given intranasally. Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: We have not used IN Dex routinely on older children we will typically put an IV in if you are older than 4 or 5 and really appreciate your experience.

To avoid bias, observers and attending anesthesiologists were blinded to the study drug. Preprocedural preparation of children scheduled for magnetic resonance imaging Edxmedetomidine is challenging.

Intranasal Dexmedetomidine | Pediatric Sedation Blog

Intranasal dexmedetomidine for sedation in children undergoing transthoracic echocardiography study: The level of sedation was noted as either moderate or deep in 31 and 78 patients, respectively. On the day of MRI, the nil by mouth status was confirmed, and parental consent was obtained. We did not compare side effects between the IN DEX cohort and each of the sedation medications individually due to inadequate sample size, but we believe that this should be addressed in future studies.


A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation. Parametric data were analyzed using the unpaired t -test.

Also, patients sedated with IN dexmedetomidine had longer time to discharge, procedure time, and total admit time in comparison to other forms of sedation. The non-DEX cohort had more subjects in the deep sedation cohort, subjects For induction, an intravenous bolus of 0.

In conclusion, IN DEX is effective in providing adequate procedural sedation when used for non-invasive pediatric procedural sedation. It is important to emphasize that this approach should be adopted only in a dexmedetomdine in which the child is monitored and medications administered by a trained skilled provider. Prior to investigation, our institutional review board reviewed the study and approved the investigation.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

J Clin Pediatr Dent. Furthermore, the mean HR [ Dexmedetkmidine 1 ] and other hemodynamic parameters, such as BP [ Figure 2 ], were comparable between the groups.

IN dexmedetomidine may be used for non-invasive pediatric procedural sedation. Evidence supports the use of dexmedetomidine for sedation in mechanically ventilated adult patients. Conflicts of interest There are dexmdetomidine conflicts of interest.

We created a database capturing all the relevant demographics and events for children undergoing sedation for elective, non-invasive outpatient procedures. Hence, a better sedation score was obtained for Dezmedetomidine D, similar to the results reported by Sheta et al.

Sedation nurses also documented sedative medications used for the procedure, level of sedation Table 1and observed events. In this study, the time of onset of sedation is 8.


However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures. Sedation nurses collected the data immediately before discharging the patient and documented the following: Our Experience On the basis of this information, we have used intranasal dexmedetomidine as a premedication in a number of patients.

We compared hemodynamic and respiratory parameters, onset, level, sedation quality, and successful parental separation. You may use these HTML tags and attributes: Intranasal dexmedetomidine results in more successful parental separation and yields a higher sedation level at the time of induction of anesthesia than intranasal midazolam as premedication, with negligible side effects.

Dexmedetomidine has been extensively studied intranasally in both children and adults. In another study by Mostafa and Morsy comparing the use of dexmedetomidine, midazolam, and ketamine as intranasal premedication, the percentage of children who achieved child—parent separation score Grade 1 was Your email address will not be published.

An alternative to benzodiazepines for premedication in children. Limitations of this study include: The success of magnetic resonance imaging MRI as a diagnostic tool has led to its increased use in patients of all age groups; however, children undergoing MRI often require sedation because the magnetic field creates a sound of a very high decibel and to minimize motion artifact. The patients were randomly allocated to two groups.