ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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Rather, it is more likely that any relation between muscle blood flow and muscle protein synthesis is related to the delivery of amino acids.

L-Arginine as a potential ergogenic aid in healthy subjects.

These mixed compounds include 2-ethyl, GPLC a carnitine-based supplementand store-bought NO 3 supplements that were reported to be mixed with over 30 other compounds Bloomer et al. Due to the multiple roles attributable to L-Arginine, its supplementation is likely to result in increased metabolism via pathways other than NO synthesis, thus, other effects via NO-independent mechanisms may also play a role [ 24 ].

Nitrite and nitrate in human health and disease. It is also known that tolerance to high-intensity training is a function of VO 2max and submaximal exercise economy [ 21 ].

Furthermore, mitochondrial function is essential for skeletal muscle metabolism, producing adenosine triphosphate ATP synthesis from different sources carbohydrates, lipids, proteins… [ 31 ]. In patients with cardiovascular disease, intravenous and oral arginine administration have been shown to support endothelial function by enhancing vasodilation and reducing monocyte adhesion 10 — Potentia meta-analyses of the effect of creatine on exercise performance, the conclusions l-argginine also somewhat variable Between the 34 studies describing consistent protocols of nitrate supplementation, only 7 report no significant benefit at all.

Abnormal desmopressin-induced forearm vasodilatation in patients with heart failure: Sports Nutr Ther 1: However, supplementation did lower the plasma concentration of several other amino acids and increase plasma concentrations of glucagon, urea, and somatrophic hormone. Firstly, it is important to understand that the initial vascular response to exercise is capillary recruitment, followed by important changes in total muscle blood flow, being NO implicated in both [ 26 ].


The amount of nitrate that needs to be consumed to obtain ergogenic effects can be obtained through a meal of g of nitrate-rich vegetables such as beetroot, spinach, and lettuce. With the help potentixl oxygen, NOS convert arginine Arga conditionally essential amino acid i.

We reviewed 27 studies that used one of these forms of NO 3 -based supplementation.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

In such instances, the vasodilatory properties of arginine may facilitate an increase in O 2 delivery, which helps meet the increased demands caused by physical activity.

There is no doubt that endothelial and NO dysfunction is a hallmark of cardiovascular disease, namely hypertension, obesity, diabetes and malnutrition [ 56 ].

NO synthesis is known to occur through at least two physiological pathways: Effect of creatine and weight training on muscle creatine and performance in vegetarians. Thus, whereas arginine supplementation alone is likely not an effective supplement to stimulate muscle protein synthesis, it may be effective if taken in conjunction with other amino acids or possibly with meals.

Interestingly, many studies have shown that L-arginine supplementation significantly improved physical performance with greater tolerance to physical exercise [ 31 ].

Furthermore, there seems to be a dose-response relationship between NO 3 – intake and its ergogenic effects, ajd the association with oxygen consumption is not as evident [ 9 ].

The question then remains whether creatine has any ergogenic effects. Accordingly, the purpose of this review is to provide an overview on the accumulating evidence concerning not only the importance of NO and its associated precursors in exercise and sports performance, but also the inherent cardiovascular modulation during workout, as well as ascertain the possible benefits and hazards, never despising the crucial role ascribed to sports nutrition professionals.

Human muscle protein synthesis is modulated by extracellular but not intracellular amino acid availability: The dietary interest of this amino acid has substantially increased in the last years due to the importance of L-Citrulline an essential intervenient in urea cycle in liver as its precursor, which bypasses hepatic metabolism and is not a substrate for arginase enzymes [ 8 ]. As a consequence, the net balance of phenylalanine across the leg, reflecting the net balance between muscle protein synthesis and breakdown, was significantly improved by the reduction of flow due to a significant reduction in the efflux of amino acids from the intracellular space.


Nitrate and nitrite content in organically cultivated vegetables. subbjects

Journal of Strength and Conditioning Research24 5 December 16, ; Accepted Date: Hence, it has been shown that vegetarians typically are more responsive to creatine supplementation, since their initial levels are low from a diet that contains little creatine L-arginine as a potential ergogenic aid in healthy subjects. Future studies should investigate the effects of chronic supplementation on 3NT levels—a marker of protein damage.

Clinical Physiology and Functional Imaging28 5 Inorganic nitrate NO3- is abundant in numerous foodstuffs and is convertible into nitrite NO2- following ingestion. European Food Safety Authority. There were only five acute studies retrieved from the literature that evaluated exercise performance after L-arginine supplementation, three of which reported significant improvements.

It is known that an L-Arginine infusion at rest increases plasma insulin, glucagon, growth hormone, prolactin and catecolamine concentrations [ 22 ]. Within the cardiovascular system, basal endothelial NO release plays a critical role in sustaining cardiovascular health, by exerting vasodilator, anti-platelet, anti-proliferative and anti-leucocyte phenotype [ 9 ].

Nevertheless, increasing plasmatic NO 2 – levels via dietary supplementation with NO 3 – may represent a practical and cost-effective intervention to restore NO homeostasis and improve exercise tolerance in these populations [ 25 ].

One of the reasons for l-argininf lack of performance improvements following dietary nitrate ingestion in endurance-trained athletes may be due to higher baseline levels of NO [ 8 ].

Effect of creatine loading on endurance capacity and sprint power in cyclists. Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea. Journal of the International Society of Sports Nutrition7